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Syntheses and antimicrobial activities of amide derivatives of 4-[(2-isopropyl-5-methylcyclohexyl)oxo]-4-oxobutanoic acid

Year: 2011

Type: article

Abstract: Chiral 4-[(2-isopropyl-5-methylcyclohexyl)oxo]-4-oxobutanoic acid reacts with substituted anilines to produce amides 1-6 in high yields. Resulted amides 1-6 were investigated for their antifungal and antibacterial activities. Compounds 2 (96.5%) against Aspergillus fumigatus and 6 (93.7%) against Helminthosporium sativum demonstrated excellent activities. However, compounds 3 (37.6%) against Bacillus subtilis, 4 (33.2%) against Pseudomonas aurignosa, 5 against Klebsiella pneumonia demonstrated excellent growth inhibition potential.

Source: Natural Science

DOI: 10.4236/ns.2011.310110

Authors: Auj e Sana, Sher Wali Khan, Javid H. Zaidi, Nida Ambreen, Khalid Mohammed Khan, Shahnaz Perveen

Institutions: Quaid-i-Azam University, University of Karachi, International Center for Chemical and Biological Sciences, Pakistan Council of Scientific & Industrial Research

Language: English

Topic: Synthesis and Biological Evaluation

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W2005207538

FWCI:

Cites: 21

Cited by: 7

Related to: 10