Synthesis of Antiulcerative Drug Tenatoprazole
Year: 2011
Type: article
Abstract: An improved synthetic approach of tenatoprazole, an antiulcerative drug, is reported. The first step in this synthesis involves the coupling of 2-mercapto-5-methoxyimidazo[4,5-b]pyridine with 2-chloromethyl-4-methoxy-3,5-dimethylpyridine hydrochloride to afford sulfide 4, and the subsequent step of oxidation using substoichiomitric amount of hydrogen peroxide to give sulfoxide 1 quantitatively. The overall yield is around 80% for both two-step synthesis. The progress in this process is no purification process and affords the target compound with 99% purity by HPLC.
Source: Advanced materials research
Authors: Feng Yan, Kai Qi Fan, Cheng Chi, Jin Guan
Institution: Shenyang University of Chemical Technology
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: hybrid
OpenAlex ID: W2005281976