Work

Peptide-induced T-cell tolerance to prevent autoimmune diabetes in a transgenic mouse model.

Year: 1994

Type: article

Abstract: A synthetic peptide corresponding to an immunodominant epitope of lymphocytic choriomeningitis virus glycoprotein (LCMV GP) was used to prime or to tolerize CD8+ T cells in vivo, dependent on mode of immunization. Peptide-specific tolerance was then examined in transgenic mice expressing LCMV GP in the beta islet cells of the pancreas; these mice develop CD8+ T-cell-mediated diabetes within 8-14 days after LCMV infection. Specific peptide-induced tolerance prevented autoimmune destruction of beta islet cells and diabetes in this transgenic mouse model.

Source: Proceedings of the National Academy of Sciences

DOI: 10.1073/pnas.91.2.444

Authors: P Aichele, D Kyburz, P S Ohashi, B Odermatt, R M Zinkernagel, H Hengartner, H Pircher

Institution: University of Zurich

Language: English

Topic: Diabetes and associated disorders

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2005311990

FWCI: 8.615

Cites: 34

Cited by: 125

Related to: 10