Work

Biopsy specimen identification by detection of sex chromosomes: application of in situ hybridisation.

Year: 1992

Type: article

Abstract: AIMS: To investigate the feasibility of non-radioactive in situ hybridisation (ISH) for the identification of sex-mismatched plastic embedded bone marrow biopsy specimens. METHODS: After a suspected accidental transposition of two glycol-methacrylate embedded bone marrow specimens, in situ hybridisation with sex chromosome specific probes was performed. RESULTS: Quantitative analysis of the hybridisation signals established unequivocably the origin of the specimens. CONCLUSIONS: ISH is feasible on GMA embedded bone marrow specimens, and can be used for the identification of accidentally transposed specimens provided that they are of sex-matched origin.

Source: Journal of Clinical Pathology

DOI: 10.1136/jcp.45.2.149

Authors: R E Kibbelaar, C F Leenheers-Binnendijk, P J Spaander, P M Kluin

Institution: Leiden University

Language: English

Topic: Clinical Laboratory Practices and Quality Control

Subfield: Medical Laboratory Technology

Field: Health Professions

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W2005365239