Work

Estimation of mechanical properties of a viscoelastic medium using a laser-induced microbubble interrogated by an acoustic radiation force

Year: 2011

Type: article

Abstract: An approach to assess the mechanical properties of a viscoelastic medium using laser-induced microbubbles is presented. To measure mechanical properties of the medium, dynamics of a laser-induced cavitation microbubble in viscoelastic medium under acoustic radiation force was investigated. An objective lens with a 1.13 numerical aperture and an 8.0 mm working distance was designed to focus a 532 nm wavelength nanosecond pulsed laser beam and to create a microbubble at the desired location. A 3.5 MHz ultrasound transducer was used to generate acoustic radiation force to excite a laser-induced microbubble. Motion of the microbubble was tracked using a 25 MHz imaging transducer. Agreement between a theoretical model of bubble motion in a viscoelastic medium and experimental measurements was demonstrated. Young's modulii reconstructed using the laser-induced microbubble approach were compared with those measured using a direct uniaxial method over the range from 0.8 to 13 kPa. The results indicate good agreement between methods. Thus, the proposed approach can be used to assess the mechanical properties of a viscoelastic medium.

Source: The Journal of the Acoustical Society of America

DOI: 10.1121/1.3628344

Authors: Sangpil Yoon, Salavat R. Aglyamov, Andrei B. Karpiouk, Seungsoo Kim, Stanislav Y. Emelianov

Institution: The University of Texas at Austin

Language: English

Topic: Ultrasound and Hyperthermia Applications

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

Open Access status: bronze

Funders: National Institutes of Health, National Eye Institute, National Institute of Biomedical Imaging and Bioengineering

Awards: Magneto-motive ultrasound imaging using molecular specific nanoparticles, Elasticity Imaging and Sensing using Gas Bubble Dynamics, G4037378220, G97281639