Assessment of Urinary Cotinine as a Marker of Nicotine Absorption from Tobacco Leaves: A Study on Tobacco Farmers in Malaysia
Year: 2003
Type: article
Study design: Observational Study
Abstract: Assessment of Urinary Cotinine as a Marker of Nicotine Absorption from Tobacco Leaves: A Study on Tobacco Farmers in Malaysia: Mayumi Onuki, et al. Department of Public Health, Graduate School of Medicine, The University of Tokyo—To assess dermal absorption of nicotine from tobacco leaves in relation to Green Tobacco Sickness (GTS), urinary cotinine concentrations were measured in 80 male tobacco‐growing farmers and in 40 healthy males (controls) who did not handle wet tobacco leaves in Kelantan, Malaysia. Among non‐smokers, urinary cotinine levels in farmers were significantly higher than those of controls; farmers with urinary cotinine of 50 ng/ml/m2 or above showed eye symptoms more frequently than those below this level (p<0.05). Farmers who did not wear protective equipment had subjective symptoms more frequently than those who used the equipment (p<0.05); some of these symptoms were seen more frequently in organophosphate (Tamaron) users than in non‐users. As tobacco farmers evidence a risk of nicotine poisoning from tobacco leaves, assessment including GTS together with effects of pesticides will be necessary.
Source: Journal of Occupational Health
DOI: 10.1539/joh.45.140
Authors: Mayumi Onuki, Kazuhito Yokoyama, Kaoru Kimura, Hajime Sato, Rusli Bin Nordin, Lin Naing, Yoko Morita, Tadashi Sakai, Yasuki Kobayashi, Shunichi Araki
Language: English
Subfield: Toxicology
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W2005398793