Work

Small interfering RNA-based molecular therapy of cancers

Year: 2013

Type: review

Abstract: RNA interference (RNAi) has become a gold standard for validating gene function in basic life science research and provides a promising therapeutic modality for cancer and other diseases. This mini-review focuses on the potential of small interfering RNAs (siRNAs) in anticancer treatment, including the establishment and screening of cancer-associated siRNA libraries and their applications in anticancer drug target discovery and cancer therapy. This article also describes the current delivery approaches of siRNAs using lipids, polymers, and, in particular, gold nanoparticles to induce significant gene silencing and tumor growth regression.

Source: 癌症：英文版

DOI: 10.5732/cjc.012.10280

Authors: Wei Guo, Wangbing Chen, Wendan Yu, Wenlin Huang, Wuguo Deng

Institutions: Sun Yat-sen University, Dalian Medical University, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Key Laboratory of Guangdong Province

Language: English

Topic: RNA Interference and Gene Delivery

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W2005466483

FWCI: 0.504

Cites: 40

Cited by: 82

Related to: 10