Hypoglycemic and Hypolipidemic Potentials of Extract of Vernonia calvoana on Alloxan-Induced Diabetic Albino Wistar Rats
Year: 2015
Type: article
Abstract: Objective: Investigations were carried out to evaluate the therapeutic potentials of extract of Vernonia calvoana as herbal medicines.Methods: In this study, the hypoglycemic and hypolipidemic potentials of extract of Vernonia calvoana was evaluated by using normal and alloxan-induced diabetic rats at a dose of 400 mg/kg b.w. daily for 14 days. Fasting Blood glucose levels and body weight were monitored at 7 days intervals, and different biochemical parameters, serum glucose, serum cholesterol, serum triacylglycerol, high density lipoprotein, low density lipoprotein and very low density lipoprotein were also assessed in the experimental animals.Results: It was found that extract of Vernonia calvoana showed significant hypoglycemic and hypolipidemic activity (P<0.01).Conclusion: Extracts of Vernonia calvoana showed significant hypoglycemic and hypolipidemic activity, which provides the scientific proof for their traditional claims.
Institution: University of Calabar
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W2005683602