Work

Non-replicatingToxoplasma gondiireverses tumor-associated immunosuppression

Year: 2013

Type: article

Abstract: We examined the efficacy of using attenuated non-replicating Toxoplasma gondii uracil auxotrophs that can be safely delivered as anticancer immunotherapeutics. This strategy exerted remarkable therapeutic activity in murine models of melanoma and ovarian carcinoma, and holds broad potential for the development of novel, highly effective anticancer vaccines.

Source: OncoImmunology

DOI: 10.4161/onci.26296

Authors: Barbara Fox, Kiah Sanders, David Bzik

Institution: Dartmouth College

Language: English

Topic: Immunotherapy and Immune Responses

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,913