Work

An inhibitor of protein synthesis initiation from Alhagi kirgisorum S

Year: 1990

Type: article

Abstract: Polyproanthocyanidin--a plant phenolic compound from Alhagi kirgisorum S. effectively inhibited protein synthesis in rabbit reticulocyte and wheat germ cell-free systems. Poly-proanthocyanidin inhibited translation only at the level of initiation and not at the elongation level and aminoacylation of tRNA. The inhibitory effect of the phenolic compound is due to the blockage of the ternary complex formation of eIF-2 with GTP and initiator Met-tRNA.

Source: FEBS Letters

DOI: 10.1016/0014-5793(90)81448-w

Authors: Salim K. Smailov, Bektas G. Mukhamedzhanov, Anatoly V. Lee, Bulat K. Iskakov, Oleg N. Denisenko

Institutions: National Academy of Sciences of the Republic of Kazakhstan, Institute of Protein Research, Academy of Sciences of the Soviet Union

Language: English

Topic: RNA and protein synthesis mechanisms

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W2006022036

FWCI: 0.12

Cites: 14

Cited by: 6

Related to: 10