Work

Design, Synthesis and Evaluation of Dual-Modality Glyco-Nanoparticles for Tumor Imaging

Year: 2013

Type: article

Abstract: d-Glucosamine (DG) was conjugated to a core-cross linked polymeric micelle (CCPM) system equipped with both a near-infrared fluorophore (NIRF) and a gamma emitter (111In). The resultant nano-scale tumor-targeting imaging tracer, 111In-DG-NIRF-CCPM, selectively accumulated in a human epithelial carcinoma A-431 xenograft model in mice. At 24 hrs post injection, the tumor uptake was 2.62 ± 0.80 % of the injected dose per gram of tissue (%ID/g). Tumors were clearly delineated in both single-photon emission computed tomography (SPECT) and optical imaging. The results suggest that the prepared imaging tracer is a promising agent for tumor diagnosis.

Source: Molecules

DOI: 10.3390/molecules18066425

Authors: Hua Zhu, Jun Zhao, Xinfeng Lin, Ye Hong, Chun Li, Zhi Yang

Institutions: Peking University Cancer Hospital, The University of Texas MD Anderson Cancer Center, China Institute of Atomic Energy

Language: English

Topic: Radiopharmaceutical Chemistry and Applications

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,258