Work

Leukocyte Depletion During CPB: Effects on Inflammation and Lung Function

Year: 2013

Type: article

Study designs: Randomized Controlled Trial, Clinical Trial

Abstract: Cardiopulmonary bypass (CPB) is related to inflammatory response and pulmonary dysfunction. The aim of this study was to evaluate the effects of CPB leukocyte filtration on inflammation and lung function after coronary artery bypass grafting (CABG). A prospective randomized study was performed to compare CABG patients undergoing CPB leukocyte filtration (n = 9) or standard CPB (n = 11). Computed tomography, oxygenation, leukocyte count, hemodynamic data, PaO2/FiO2, shunt fraction, interleukins, elastase, and myeloperoxidase were evaluated. Data were analyzed using two-factor ANOVA for repeated measurements. The filtered group showed lower neutrophil counts up to 50 min of CPB, lower shunt fraction up to 6 h after surgery, and lower levels of IL-10 at the end of surgery (p < 0.05). There was no statistically significant difference between groups related to other parameters. Leukodepletion during CPB results in neutrophil sequestration by a short time, decreased IL-10 serum levels, and lower worsening of lung function only temporarily.

Source: Inflammation

DOI: 10.1007/s10753-013-9730-z

Authors: Célio Gomes de Amorim, Luiz Marcelo Sá Malbouisson, Francisco Costa da Silva, Alfredo Inácio Fiorelli, Caroline Kameio Fernandes Murakami, Maria José Carvalho Carmona

Institutions: Universidade de São Paulo, Instituto do Coração - HCFMUSP

Language: English

Topic: Cardiac and Coronary Surgery Techniques

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,790