Work

Natalizumab May Improve Cognition and Mood in Multiple Sclerosis

Year: 2012

Type: article

Abstract: Immunomodulating therapies may prevent relapses in multiple sclerosis and stabilize neurological status. However, little is known about the influence particularly of newer drugs on cognitive functions. We conducted an open-label prospective study to demonstrate whether natalizumab is apt to improve cognitive functions and mood in 29 patients tested psychometrically while under treatment for 6 months. We found improvements in some measures of attention, memory, mood, and well-being, but no deterioration, although patients suffered from their diseases for more than 10 years and had an EDSS score of 3.5. It is concluded that natalizumab is able to stabilize or improve cognition and mood even in longer-lasting multiple sclerosis.

Source: European Neurology

DOI: 10.1159/000334722

Authors: C. Lang, C. Reiss, M. Mäurer

Institutions: Friedrich-Alexander-Universität Erlangen-Nürnberg, Caritas-Krankenhaus Bad Mergentheim

Language: English

Topic: Multiple Sclerosis Research Studies

Subfield: Pathology and Forensic Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2007125032

FWCI: 2.302

Cites: 12

Cited by: 29

Related to: 10