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BRAF gene: From human cancers to developmental syndromes

Year: 2014
Type: review
Abstract: The BRAF gene encodes for a serine/threonine protein kinase that participates in the MAPK/ERK signalling pathway and plays a vital role in cancers and developmental syndromes (RASopathies). The current review discusses the clinical significance of the BRAF gene and other members of RAS/RAF cascade in human cancers and RAS/MAPK syndromes, and focuses the molecular basis and clinical genetics of BRAF to better understand its parallel involvement in both tumourigenesis and RAS/MAPK syndromes-Noonan syndrome, cardio-facio-cutaneous syndrome and LEOPARD syndrome.
DOI: 10.1016/j.sjbs.2014.10.002
Authors: Muhammad Ramzan Manwar Hussain, Mukhtiar Baig, Hussein Sheik Ali Mohamoud, Zaheer Ulhaq, Daniel C. Hoessli, Ghaidaa Siraj Khogeer, Ranem Radwan Al-Sayed, Jumana Yousuf Al-Aama
Institutions: King Abdulaziz University, Institute of Microbiology, University of Chinese Academy of Sciences, St George's, University of London, University of Karachi, International Center for Chemical and Biological Sciences
Language: English
Open Access status: hybrid
Estimated APC paid: $1,490
OpenAlex ID: W2007228036
FWCI: 0.316
Cites: 134
Cited by: 120
Related to: 10