Year: 2000
Type: article
Abstract: Multiple chondromas were observed in one young adult (18 weeks old) male B6C3F1 strain mouse used in toxicity tests for safety assessment of chemicals. Solitary chondroma composed of mature cartilage cells was found in different sites of the ribs. In addition, chondrosarcoma was observed in the lumbar vertebra and abdominal cavity of one old (109 weeks old) male mouse of the same strain. The sarcoma was composed of mixed atypical chondrocytic and spindle-shaped cells, extending into the surrounding tissue. This is a report on spontaneous multiple chondromas occurring in the B6C3F1 mouse.
Source: Journal of Toxicologic Pathology
DOI: 10.1293/tox.13.131
Authors: Masayo Hosoi, Kazushige Hasegawa, Tohru Kihara, Rumiko Miyajima, Shinji Yamamoto, Shin-ichi Mikami, Seiki Yamakawa, Hijiri Iwata, Yasuhiko Hirouchi, Makoto Enomoto
Institution: BioSafety Research Center
Language: English
Subfield: Orthopedics and Sports Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2007241206