Year: 1997
Type: article
Abstract: The effects of secretin administration on the rat adrenal cortex have been investigated both in virro and in vivo.Secretin significantly raised basal aldosterone production by dispersed zona glomerulosa (ZG) cells, without affecting corticosterone secretion of zona fasciculata (ZF) and reticularis (ZR) cells.Both the acute and chronic administration of secretin increased the plasma concentrations of ACTH, aldosterone and corticosterone.The prolonged secretin treatment raised adrenal weight, as well as the volume of ZG and the number of its cells; the average volume of ZF cells was increased, while ZR displayed a marked hyperplasia coupled with a sizable lowering in the volume of its cells.In light of these findings it is concluded that secretin stimulates rat hypothalamo-pituitary-adrenal axis.The secretin-induced rise in corticosterone secretion and adrenal hypertrophy seems to be exclusively due to the stimulation of pituitary ACTH release.In contrast, the increase in aldosterone secretion appears also to involve a direct stimulatory action of secretin on the ZG.
Source: Biomedical Research
Institution: University of Padua
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2007453022