This work has been retracted.
RETRACTED: The protein LEM promotes CD8 + T cell immunity through effects on mitochondrial respiration
Year: 2015
Type: article
Abstract: Protective CD8(+) T cell-mediated immunity requires a massive expansion in cell number and the development of long-lived memory cells. Using forward genetics in mice, we identified an orphan protein named lymphocyte expansion molecule (LEM) that promoted antigen-dependent CD8(+) T cell proliferation, effector function, and memory cell generation in response to infection with lymphocytic choriomeningitis virus. Generation of LEM-deficient mice confirmed these results. Through interaction with CR6 interacting factor (CRIF1), LEM controlled the levels of oxidative phosphorylation (OXPHOS) complexes and respiration, resulting in the production of pro-proliferative mitochondrial reactive oxygen species (mROS). LEM provides a link between immune activation and the expansion of protective CD8(+) T cells driven by OXPHOS and represents a pathway for the restoration of long-term protective immunity based on metabolically modified cytotoxic CD8(+) T cells.
Source: Science
Language: English
Topic: T-cell and B-cell Immunology
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: green
Funders: Wellcome Trust, Cancer Research UK, British Heart Foundation, Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung, Eidgenössische Technische Hochschule Zürich, National Institutes of Health, Medical Research Council, National Institute of Allergy and Infectious Diseases
Awards: Ischemia-reperfusion injury in transplantation: novel cytoprotection strategies, G3525454491, Investigating the metabolic control of T cell migration: implications for immune inflammation in physiology and cardiovascular metabolic disease, Development and Persistence of Memory T Lymphocytes, Regulation of adaptive immunity during acute and persistent viral infections, G683029657, G7648759739, G8201278142
OpenAlex ID: W2008234142