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Acute Lymphoblastic Leukemia with Hypereosinophilia and 9p21 Deletion: Case Report and Review of the Literature

Year: 2008

Type: article

Abstract: Acute lymphoblastic leukemia (ALL) associated with eosinophilia is very rare, with approximately 44 reported cases. We are reporting this case not only because of the rarity of ALL with peripheral blood eosinophilia, but also because we observed a homozygous deletion of the 9p21 locus corresponding to the p16 gene, a cytogenetic abnormality that was not reported in other documented cases. ALL with eosinophilia must be considered a distinct clini-copathologic entity. It is very important for clinicians to be aware of this specific manifestation of ALL within the context of a persistent peripheral eosinophilia, particularly if no lymphoblasts are present in the peripheral blood.

Source: Laboratory Hematology

DOI: 10.1532/lh96.07018

Authors: Guido D'Angelo, Anna Maria Hotz, Paolo Todeschin

Institutions: Azienda Ospedaliera Sant’Antonio Abate di Gallarate, Aziende Socio Sanitarie Territoriale dei Sette Laghi

Language: English

Topic: Acute Lymphoblastic Leukemia research

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W2008365146

FWCI: 0.637

Cites: 9

Cited by: 15

Related to: 10