Work

Voltage‐gated K+ currents of mouse dendritic cells

Year: 1995

Type: article

Abstract: Dendritic cells (DC) were enriched from murine spleen by exploring their intermediate density and transient weak adherence. The isolated population contained excellent antigen presenting cells with high surface expression of major histocompatibility complex (MHC) class II determinants thus exhibiting crucial immunofunctional characteristics of DC. Cells of typical dendritic shape were electrophysiologically analysed using the whole cell configuration of the patch clamp technique. All 26 cells expressed only outward K+ currents comparable to those detected in cytokine-activated microglia. Co-purified splenic macrophages, in contrast, displayed an inward rectifying K+ current.

Source: FEBS Letters

DOI: 10.1016/0014-5793(95)01029-e

Authors: Hans-Georg Fischer, Claudia Eder

Institutions: Heinrich Heine University Düsseldorf, Humboldt-Universität zu Berlin, Charité – Universitätsmedizin Berlin

Language: English

Topic: Ion channel regulation and function

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W2008708257

FWCI: 0.104

Cites: 14

Cited by: 22

Related to: 10