Work

Expression of bcl-x in T cells

Year: 1996

Type: article

Abstract: The thymus is a major site of apoptosis where programmed cell death is involved in the deletion of self-reactive T cells. We have investigated the role of bcl-x in T cells by defining the expression of its two isoforms, bcl-x and bcl-xs, in a series of human thymocyte cell lines and in human T lymphocytes using the ribonuclease protection assay. Bcl-x1 was the predominant isoform expressed in T cell lines and in T lymphocytes, where expression was further enhanced by PMA/ionomycin. This broad expression supports a central role for bcl-x in thymocyte development perhaps through post-transcriptional regulation.

Source: Leukemia Research

DOI: 10.1016/0145-2126(95)00160-3

Authors: Ginette Y. Michaud, Hiroshi Kamesaki, Jeffrey Cossman

Institutions: Georgetown University, Georgetown University Medical Center, Aichi Cancer Center, Aichi Cancer Center Research Institute

Language: English

Topic: Cell death mechanisms and regulation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,910