Work

Comparison of Enzymatic and Microbiological Gentamicin Assays

Year: 1974

Type: article

Abstract: The correlation coefficient between the rapid enzymatic and the overnight microbiological assays for 211 urine and serum specimens was 0.96. The 95% confidence limits yielded a correlation coefficient between 0.92 and 0.98. Both methods tended to underestimate the amount of a gentamicin added to urine. When only serum samples were considered, the predicted value obtained from the linear regression analysis of either method was within 0.57 mug/ml 99% of the time. This high degree of positive correlation will permit safe rapid adjustment of individualized patient gentamicin dosages.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.6.3.316

Authors: Arnold L. Smith, J. Allan Waitz, David H. Smith, Edwin M. Oden, Barbara B. Emerson

Institution: Boston Children's Hospital

Language: English

Topic: Antibiotics Pharmacokinetics and Efficacy

Subfield: Pharmacology (medical)

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Institute of Allergy and Infectious Diseases