Work

Comprehensive cytogenomic profile of the in vitro neuronal model SH-SY5Y

Year: 2012

Type: article

Abstract: The widely studied SH-SY5Y human neuroblastoma cell line provides a classic example of how a cancer cell line can be instrumental for discoveries of broad biological and clinical significance. An important feature of the SH-SY5Y cells is their ability to differentiate into a functionally mature neuronal phenotype. This property has conferred them the potential to be used as an in vitro model for studies of neurodegenerative and neurodevelopmental disorders. Here, we present a comprehensive assessment of the SH-SY5Y cytogenomic profile. Our results advocate for molecular cytogenetic data to inform the use of cancer cell lines in research.

Source: Neurogenetics

DOI: 10.1007/s10048-012-0350-9

Authors: Mohammed Yusuf, Kay Leung, Keith J. Morris, Emanuela V. Volpi

Institutions: Centre for Human Genetics, University of Oxford, University of Nottingham

Language: English

Topic: Genomic variations and chromosomal abnormalities

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,590