Work

Isolation and structure elucidation of a novel griseorhodin.

Year: 1979

Type: article

Abstract: Three antibiotics possessing cytotoxic properties were isolated from a strain of Streptomyces griseus (FCRC-57). One was found to be identical with griseorhodin A. A second, FCRC-57-U, was found to be identical to griseorhodin C. FCRC-57-G is a new antibiotic structurally related to griseorhodins A and C, and is active against KB cells in vitro. The structure of this new antibiotic was determined using mass spectrometry, proton and carbon nuclear magnetic resonance spectroscopy and synthesis.

Source: The Journal of Antibiotics

DOI: 10.7164/antibiotics.32.197

Authors: RONALD M. STROSHANE, JAMES A. CHAN, ELIZABETH A. RUBALCABA, ALINE L. GARRETSON, ADORJAN A. ASZALOS, PETER P. ROLLER

Institutions: Frederick National Laboratory for Cancer Research, National Institutes of Health, National Cancer Institute

Language: English

Topic: Microbial Natural Products and Biosynthesis

Subfield: Pharmacology

Field: Medicine

Domain: Health Sciences

Open Access status: bronze

Funders: National Institutes of Health, National Cancer Institute

OpenAlex ID: W2009598007

FWCI: 0.817

Cites: 14

Cited by: 45

Related to: 10