Year: 2007
Type: review
Abstract: Mast cells – an introduction Mast cell – a potent effector cell Mast cells and atherosclerosis Coronary mast cells in acute human myocardial infarction Animal models of plaque erosion and rupture Clinical approaches to stabilize mast cells in the atherosclerotic plaque Conclusions Abstract The aim of the present review is to discuss the participation of mast cells in the pathogenesis of erosion and rupture of atherosclerotic plaques, the major causes behind acute coronary syndromes and myocardial infarction. We present ex vivo observations describing mast cells and their activation in human atherosclerotic plaques and discuss in vitro and in vivo data showing that mast cells are potential regulators of inflammation, immunity and adverse remodeling, including matrix remodeling and cell death. Furthermore, we focus on studies that have been performed with human tissues and human mast cells, but when appropriate, we also discuss observations made in animal models. Finally, we present potential pharmacological means to modulate mast cell responses in the arterial vessel walls.
Institution: Wihuri Research Institute
Language: English
Topic: Mast cells and histamine
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W2010220972