Work

The role of the antioxidant: Selenopyran in the stability of the antioxidant system to toxic effect of cadmium chloride

Year: 2007

Type: article

Abstract: The purpose of the present work was, under conditions of the model experiment on rats, to tap the information about the features of shortterm acclimatization of the antioxidant system in various organs to toxicity of cadmium at stages of an ontogenesis and about the preventive role of the antioxidant selenopyran in this process. The obtained results showed the ontogenetic differences in the adaptive reactivity of the enzymatic antioxidant defense system in the most important organs and tissues of rats under conditions of oxidative stress induced by cadmium. The ontogenetic differences of Se redistribution in a body under influence of cadmium administration were found. The discovered decrease of Se concentration in the liver of young animals and the increase of its concentration in the liver of old animals correlated positively with the changes of GPx activity. Preventive administration of selenopyran (9- phenyl-simmetrical octa-hydroselenoxanthene) to old animals reduced the oxidative stress intensity. Animals of all age groups showed higher selenium concentration in the tissues and the increase in the selenium-dependent GPx activity.

Source: Biotechnology in Animal Husbandry

DOI: 10.2298/bah0701181k

Authors: U. Kravchenko, G. Borjaev, M. Nevitov, A. Ostapchuk, E. Kistanova

Institutions: Penza State Agricultural Academy, Bulgarian Academy of Sciences, Institute of Biology and Immunology of Reproduction

Language: English

Topic: Selenium in Biological Systems

Subfield: Nutrition and Dietetics

Field: Nursing

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W2010224207

FWCI:

Cites: 12

Cited by: 1

Related to: 10