Work

Human Drug Discrimination and Multiple Chemical Sensitivity: Caffeine Exposure as an Experimental Model

Year: 1997

Type: article

Abstract: Multiple chemical sensitivity is a controversial diagnosis. Rigorous, controlled, laboratory-based research can reduce this controversy and lead to potential clinical confirmatory tests. The literature on human caffeine discrimination provides a rigorous methodology that can address reports that patients who suffer multiple chemical sensitivity (MCS) are sensitive to usually well-tolerated chemical doses; the studies require patients to discriminate caffeine from placebo under double-blind conditions. Several issues relevant to the conduct of caffeine discrimination studies using MCS patients as subjects are addressed; these issues include study design, determination of safe and tolerable training doses, and discrimination training. Such research will benefit patients and clinicians dealing with a diagnosis of MCS.

Source: Environmental Health Perspectives

DOI: 10.1289/ehp.97105s2509

Authors: T Eissenberg, R R Griffiths

Institutions: Johns Hopkins University, Johns Hopkins Medicine

Language: English

Topic: Indoor Air Quality and Microbial Exposure

Subfield: Health, Toxicology and Mutagenesis

Field: Environmental Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $4,500