Work

Physiological functions of the TRPM4 channels via protein interactions

Year: 2015

Type: article

Abstract: Transient Receptor Potential, Melastatin-related, member 4 (TRPM4) channels are Ca2(+)-activated Ca2(+)-impermeable cation channels. These channels are expressed in various types of mammalian tissues including the brain and are implicated in many diverse physiological and pathophysiological conditions. In the past several years, the trafficking processes and regulatory mechanism of these channels and their interacting proteins have been uncovered. Here in this minireview, we summarize the current understanding of the trafficking mechanism of TRPM4 channels on the plasma membrane as well as heteromeric complex formation via protein interactions. We also describe physiological implications of protein-TRPM4 interactions and suggest TRPM4 channels as therapeutic targets in many related diseases.

Source: BMB Reports

DOI: 10.5483/bmbrep.2015.48.1.252

Authors: Chang-Hoon Cho, Young-Sun Lee, Eunju Kim, Eun Mi Hwang, Jae-Yong Park

Institutions: Korea University, Gyeongsang National University, Korean Association Of Science and Technology Studies, Korea Institute of Science and Technology, Korea University of Science and Technology

Language: English

Topic: Ion Channels and Receptors

Subfield: Sensory Systems

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $550