Year: 1999
Type: article
Abstract: Sera of 20 children falsely identified as positive for hepatitis C virus antibody (Anti-HCV) by a second generation anti-HCV-assay kit (Imucheck-HCV Ab "Kokusai") were re-tested using a new third generation anti-HCV-assay kit (Imucheck x F-HCV C50 Ab "Kokusai"). Seventeen of the samples were reclassified as negative and only three remained positive. Changing well solids in the anti-HCV-assay kit from casein to bovine serum albumin appears to have improved the false-positive rate, most likely as a result of decreased non-specific adsorption of casein antibodies.
DOI: 10.1620/tjem.187.257
Authors: Kohachiro Sugiyama, Kenji Goto, Yoshishige Miyake, Fumiya Mizutani, Koji Terabe, Rou Li, Hiroko Maniwa, Yoshikazu Kawabe, Yoshiro Wada
Institution: Nagoya City University
Language: English
Topic: Hepatitis C virus research
Subfield: Hepatology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2010670677