Work

OR7-001 – By chip pyrin binds the IRF2 promoter

Year: 2013

Type: article

Abstract: The gene causing familial Mediterranean fever (FMF), MEFV , encodes a protein, pyrin, which is expressed at high levels in granulocytes, monocytes, dendritic cells and in some human myeloid leukemia cell lines, such as THP.1. Studies of pyrin localization show a cell-type dependency. In transfection experiments full-length pyrin is cytoplasmic and associates with the cytoskeleton. However, native pyrin is predominantly nuclear in granulocytes, dendritic cells, and synovial fibroblasts, but it is cytoplasmic in monocytes. Recent studies have implicated pyrin in the regulation of IL-1b and NF Κ B activation.

Source: Pediatric Rheumatology

DOI: 10.1186/1546-0096-11-s1-a102

Authors: G Wood, Y Kanno, J Balow, H-W Sun, I Aksentijevich, DL Kastner

Institutions: National Human Genome Research Institute, Lemann Center for Brazilian Studies, National Institutes of Health, National Institute of Arthritis and Musculoskeletal and Skin Diseases

Language: English

Topic: Inflammasome and immune disorders

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,090