Clinical Relevance of CD-68 Positive Cells in Normal Buccal Mucosa in Patients with Inflammatory Bowel Disease
Year: 2012
Type: article
Study design: Observational Study
Abstract: The aim of this study was to investigate the presence of microaggregates of macrophages (CD-
68 positive cells) in macroscopically normal buccal mucosa in patients with inflammatory bowel disease
(IBD). Fifty two patients with clinically and pathohistologically diagnosed IBD, thirty patients with
Crohn’s disease (CD), twenty two patients with ulcerative colitis (UC), and twenty five controls, matched
for sex and age, were involved. The occurrence of CD-68 positive cells microaggregates was more frequent
in CD patients comparing with UC patients (P = 0.0093), and the controls (P = 0.0001) respectively.
There was no statistically significant difference in occurrence of CD-68 positive microaggregates in
patients with positive microbiological findings (P = 0.8258). The results suggest that microaggregates of
macrophages are more frequently present in apparently normal buccal mucosa in patients with CD than in
patients with UC independently of microbiological findings. Therefore, it could be a potential marker for
differentiating patients with Crohn’s disease from UC patients, when standard tools failed. (doi:
10.5562/cca1779)
Source: Croatica Chemica Acta
DOI: 10.5562/cca1779
Institutions: University of Rijeka, Klinički Bolnički Centar Rijeka
Language: English
Topic: Inflammatory Bowel Disease
Subfield: Genetics
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W2010768982