Work

Sperm Protein 17 Is Expressed in Human Somatic Ciliated Epithelia

Year: 2004

Type: article

Abstract: It was once believed that sperm protein 17 (Sp17) was expressed exclusively in the testis and that its sole function was to bind to the oocyte during fertilization. However, immunohistochemistry of the human respiratory airways and reproductive systems show that it is abundant in ciliated cells but not in human cells with stereocilia and microvilli. The high degree of sequence conservation throughout its N-terminal half, and the presence of an A-kinase anchoring protein (AKAP)-binding motif within this region, suggest that Sp17 plays a regulatory role in a PKA-independent AKAP complex in both male germinal and ciliated somatic cells.

Source: Journal of Histochemistry & Cytochemistry

DOI: 10.1177/002215540405200414

Authors: Fabio Grizzi, Maurizio Chiriva-Internati, Barbara Franceschini, Klaus Bumm, Piergiuseppe Colombo, Michele Ciccarelli, Elena Donetti, Nicoletta Gagliano, Paul L. Hermonat, Robert K. Bright, Magda Gioia, Nicola Dioguardi, W. Martin Kast

Institutions: IRCCS Humanitas Research Hospital, Texas Tech University, Texas Tech University Health Sciences Center, University of Milan, University of Arkansas Medical Center, University of Arkansas for Medical Sciences, University of Southern California, USC Norris Comprehensive Cancer Center

Language: English

Topic: Sperm and Testicular Function

Subfield: Reproductive Medicine

Field: Medicine

Domain: Health Sciences

Open Access status: bronze

OpenAlex ID: W2011308482

FWCI: 3.564

Cites: 15

Cited by: 42

Related to: 10