Work

Macrophage-lymphocyte interactions mediate anti-Burkholderia pseudomallei activity

Year: 1998

Type: article

Abstract: The mechanisms involved in the pathogenesis of melioidosis, caused by the intracellular bacterium Burkholderia pseudomallei, are unclear. C57BL/6 mice are resistant to infection, while BALB/c mice are highly susceptible. Previous studies have demonstrated that peritoneal exudate cell preparations enriched for macrophages are capable of effectively eliminating intracellular pathogens. In this study we present evidence showing that interaction of macrophages with lymphocytes is necessary for efficient anti-B. pseudomallei activity.

Source: FEMS Immunology & Medical Microbiology

DOI: 10.1111/j.1574-695x.1998.tb01175.x

Authors: Glen C Ulett, Natkunam Ketheesan, Robert G Hirst

Institutions: James Cook University, The University of Queensland

Language: English

Topic: Burkholderia infections and melioidosis

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W2011646644