Work

Tissue‐specific alternative splicing of mouse brain type ryanodine receptor/calcium release channel mRNA

Year: 1996

Type: article

Abstract: We detected alternative splicing of the mouse brain type ryanodine receptor (RyR3) mRNA. The splicing variant was located in the transmembrane segment. The non-splicing type (RyR3-II) included a stretch of 341 bp, and that of the 13th codon was stop codon TAA. Reverse transcription-polymerase chain reaction (RT-PCR) analysis shows that RyR3-II mRNA was expressed in various peripheral tissues and brain at all developmental stages. However, interestingly, the splicing type (RyR3-I) mRNA was detected only in the cerebrum. These findings suggest that the splicing variants RyR3-I and RyR3-II may generate functional differences of RyR3 in a tissue-specific manner.

Source: FEBS Letters

DOI: 10.1016/0014-5793(96)01022-8

Authors: Ryosuke Miyatake, Aizo Furukawa, Masayuki Matsushita, Kazuhiko Iwahashi, Kazuhiko Nakamura, Yoshiyuki Ichikawa, Hiroshi Suwaki

Institution: Kagawa University

Language: English

Topic: RNA Research and Splicing

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: bronze

OpenAlex ID: W2011809437

FWCI: 1.055

Cites: 36

Cited by: 36

Related to: 10