Work

Aerobic oxidation of thiols to disulfides by heterogeneous goldcatalysts

Year: 2011

Type: article

Abstract: Thiols are smoothly and efficiently oxidized to disulfides (RSSR) with air in the presence of gold nanoparticles supported on CeO2 in absence of solvent, as well as in aqueous solutions and neutral pH. It is shown that the reaction can occur through the coupling of two sulphur radicals on the metal surface. The sulphur radicals are formed from thiols by one-electron oxidation with the metal. This reaction mechanism strongly resembles that found for sulfhydryl oxidases, a class of enzymes which are involved in the oxidative protein folding through de novo formation of disulfides from thiols.

Source: Chemical Science

DOI: 10.1039/c1sc00466b

Authors: Avelino Corma, Tania Ródenas, Maria J. Sabater

Institutions: Consejo Superior de Investigaciones Científicas, Instituto de Tecnología Química, Universitat Politècnica de València

Language: English

Topic: Sulfur-Based Synthesis Techniques

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: bronze

Funders: Generalitat Valenciana, Ministerio de Ciencia e Innovación

Award: G743618450