Work

Epithelial-Immune Cell Interaction in Dry Eye

Year: 2008

Type: review

Abstract: Dry eye is a potent stimulus of both innate and adaptive immune systems. At the nexus of the dry eye inflammatory/immune response is the dynamic interplay between the ocular surface epithelia and the bone marrow-derived immune cells. On the one hand, ocular surface epithelial cells play a key initiating role in this inflammatory reaction. On the other hand, they are targets of cytokines produced by activated T cells that are recruited to the ocular surface in response to dry eye. This interaction between epithelial and immune cells in dry eye will be thoroughly reviewed.

Source: Cornea

DOI: 10.1097/ico.0b013e31817f4075

Authors: Stephen C Pflugfelder, Cintia S de Paiva, De-Quan Li, Michael E Stern

Institution: Baylor College of Medicine

Language: English

Topic: Ocular Surface and Contact Lens

Subfield: Public Health, Environmental and Occupational Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Eye Institute