Year: 2013
Type: article
Abstract: Diospyros lotus is traditionally used in various diseases including inflammation. In the current study an effort has been made to identify a bioactive constituent from D. lotus in order to scientifically validate its use in inflammatory disorders. Diospyrin was isolated from D. lotus and exhibited significant lipoxygenase (LOX) inhibitory activity (IC50 value: 31.89 ± 0.14 μmol). Molecular docking revealed significant molecular interactions between Diospyrin and LOX showing promising potential for further optimization as a potential anti-inflammatory lead compound.
Institutions: University of Peshawar, University of Karachi
Language: English
Topic: Bioactive natural compounds
Subfield: Drug Discovery
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $2,490
OpenAlex ID: W2012176901