Sirtuins in Epigenetic Regulation
Year: 2015
Type: review
Abstract: Sirtuins 2353 2. Yeast Sirtuins in Epigenetic Regulation 2353 2.1.Role of SIR2 in Regulating Transcriptional Silencing 2353 2.2.Role of SIR2 in Regulating rDNA Recombination 2354 2.3.Role of SIR2 in Regulating DNA Repair 2354 2.4.Interaction between SIR2 and Other Epigenetic Markers/Enzymes 2354 2.4.1.SIR2 Interacts with Other Proteins That Control Histone Acetylation 2354 2.4.2.SIR2 and Histone Methylation 2354 2.5.Functions of Other Yeast Sirtuins in Epigenetic Regulation 2355 3. Mammalian Sirtuins in Epigenetic Regulation 2355 3.1.Epigenetic Functions of SIRT1 2355 3.1.1.SIRT1's Histone Deacetylase Activity Regulates Chromatin Structure and Transcription 2355 3.1.2.SIRT1 Regulates Other Epigenetic Enzymes 2361 3.1.3.SIRT1 and Constitutive Heterochromatin 2362 3.1.4.SIRT1 Deacetylates and Regulates Transcription Factors 2362 3.2.SIRT2 in Epigenetic Regulation 2364 3.2.1.SIRT2 Deacetylates Histones and Regulates Cell Cycle, DNA Repair, and Transcription 2364 3.2.2.SIRT2 Deacetylates Transcription Factors and Regulates Transcription 2364 3.3.SIRT6 in Epigenetic Regulation 2365 3.3.1.SIRT6 in Gene Silencing 2365 3.3.2.SIRT6 in Genome Stability and DNA Repair 2366 3.4.Role of SIRT7 in Epigenetic Regulation 2366 4. Summary and Outlook 2366 4.1.Value of Model Organisms 2366 4.2.Connection between Sirtuins, Metabolism, and Epigenetics 2366 4.3.Recruitment of Mammalian Sirtuins to Different Regions of Chromatin or DNA Damage Sites 2367 4.4.Possibility of New Epigenetic Marks 2367 4.5.Function of Different Histone Acetylation Sites 2367 4.6.Drug Discovery Targeting Sirtuins and the Importance of Biochemical Assays
Source: Chemical Reviews
DOI: 10.1021/cr500457h
Authors: Hui Jing, Hening Lin
Institution: Cornell University
Language: English
Subfield: Geriatrics and Gerontology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,500
OpenAlex ID: W2012233199