Work

Long Intergenic Noncoding RNAs: New Links in Cancer Progression

Year: 2011

Type: review

Abstract: The process of cancer metastasis involves a series of sequential and complex steps. Here we give a perspective on recent results regarding noncoding transcription in cancer progression, focusing on the emerging role of long intergenic noncoding RNAs (lincRNAs). LincRNAs target chromatin modification complexes or RNA-binding proteins to alter gene expression programs. Similarly to miRNAs, lincRNAs exhibit distinct gene expression patterns in primary tumors and metastases. We discuss how lincRNAs can be used for cancer diagnosis and prognosis and serve as potential therapeutic targets.

Source: Cancer Research

DOI: 10.1158/0008-5472.can-10-2483

Authors: Miao-Chih Tsai, Robert C. Spitale, Howard Y. Chang

Institutions: Howard Hughes Medical Institute, Stanford Medicine, Stanford University

Language: English

Topic: Cancer-related molecular mechanisms research

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: Howard Hughes Medical Institute, National Cancer Institute, National Institute of Arthritis and Musculoskeletal and Skin Diseases