Work

Effects of vancomycin on renal function in rats

Year: 1981

Type: article

Abstract: To assess the effects of vancomycin on the kidney, we gave rats doses of 10, 50, 100, 200, and 400 mg/kg per day. Creatinine clearance and urine protein excretion did not differ significantly from the control values. Urine osmolality was unchanged. Mild histological changes occurred in rats given the highest dose. We conclude that although histopathological changes occurred at high doses, vancomycin does not alter renal function in rats.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.19.2.306

Authors: G R Aronoff, R S Sloan, C B Dinwiddie, M D Glant, N S Fineberg, F C Luft

Institution: Indiana University School of Medicine

Language: English

Topic: Antibiotics Pharmacokinetics and Efficacy

Subfield: Pharmacology (medical)

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2012442465

FWCI: 0.363

Cites: 6

Cited by: 49

Related to: 10