Work

Mathematical models for insulin secretion in pancreatic β-cells

Year: 2012

Type: review

Abstract: Insulin secretion is one of the most characteristic features of β-cell physiology. As it plays a central role in glucose regulation, a number of experimental and theoretical studies have been performed since the discovery of the pancreatic β-cell. This review article aims to give an overview of the mathematical approaches to insulin secretion. Beginning with the bursting electrical activity in pancreatic β-cells, we describe effects of the gap-junction coupling between β-cells on the dynamics of insulin secretion. Then, implications of paracrine interactions among such islet cells as α-, β-, and δ-cells are discussed. Finally, we present mathematical models which incorporate effects of glycolysis and mitochondrial glucose metabolism on the control of insulin secretion.

Source: Islets

DOI: 10.4161/isl.19569

Authors: Kyungreem Han, Hyuk Kang, Jinwoong Kim, MooYoung Choi

Institutions: National Institute for Mathematical Sciences, Seoul National University, Center for Theoretical Physics

Language: English

Topic: Pancreatic function and diabetes

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: National Research Foundation, Korea Research Council of Fundamental Science and Technology, National Research Foundation of Korea