Work

Role of the Cytomegalovirus (CMV)‐Antigenemia Assay as a Predictive and Follow‐Up Detection Tool for CMV Disease in AIDS Patients

Year: 1999

Type: article

Abstract: Forty-two patients were evaluated to determine the value of the CMV antigenemia (CMV-Ag) test as a follow-up marker as well as a prediction marker of CMV disease. Twenty patients were positive for at least one positive CMV-Ag assay and 9 of them developed CMV retinitis. With the threshold value (10 positive cells), sensitivity was 56% and specificity was 94%. The CMV-Ag assay, with the threshold value, produced high specificity, positive predictive value and negative predictive value but relatively poor sensitivity. Eight patients experienced CMV disease relapse a total of 16 times. At relapse, 8 of the 16 times showed negative for CMV-Ag assay; 7 underwent systemic maintenance while 1 underwent local maintenance. It is inferred that the CMV-Ag test is a poor follow-up marker to detect the relapse of CMV disease, particularly in patients undergoing systemic maintenance.

Source: Microbiology and Immunology

DOI: 10.1111/j.1348-0421.1999.tb03356.x

Authors: Yoshihiko Hoshino, Yoichi Nagata, Hitomi Taguchi, Atsuko Masunaga, Yujiro Fujino, Manabu Mochizuki, Tetsuya Nakamura, Aikichi Iwamoto

Institutions: Institute of Medical Science, The University of Tokyo, The University of Tokyo, Tokyo Medical and Dental University

Language: English

Topic: Cytomegalovirus and herpesvirus research

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W2012842271

FWCI: 0.69

Cites: 23

Cited by: 5

Related to: 10