Work

Comparative Analysis of Transforming Properties of E6 and E7 from Different Beta Human Papillomavirus Types

Year: 2011

Type: article

Abstract: The cutaneous beta human papillomavirus (beta HPV) types appear to be involved in skin carcinogenesis. However, only a few beta HPVs have been investigated so far. Here, we compared the properties of E6 and E7 oncoproteins from six uncharacterized beta HPVs (14, 22, 23, 24, 36, 49). Only HPV49 E6 and E7 immortalized primary human keratinocytes and efficiently deregulated the p53 and pRb pathways. Furthermore, HPV49 E6, similarly to E6 from the oncogenic HPV16, promoted p53 degradation.

Source: Journal of Virology

DOI: 10.1128/jvi.06579-11

Authors: Iris Cornet, Véronique Bouvard, Maria Saveria Campo, Miranda Thomas, Lawrence Banks, Lutz Gissmann, Jérôme Lamartine, Bakary S. Sylla, Rosita Accardi, Massimo Tommasino

Institutions: Centre international de recherche sur le cancer, University of Glasgow, International Centre for Genetic Engineering and Biotechnology, International Centre for Genetic Engineering and Biotechnology, International Centre for Genetic Engineering and Biotechnology, DKFZ-ZMBH Alliance, Lyon 1 Université

Language: English

Topic: Cervical Cancer and HPV Research

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Association pour la Recherche sur le Cancer, Cancer Research UK, Associazione Italiana per la Ricerca sul Cancro

OpenAlex ID: W2012898404

FWCI: 3.742

Cites: 19

Cited by: 87

Related to: 10