Influence de l'apport et du mode d'administration de triglycérides sur l'absorption et l'hydrolyse des phosphatidylcholines de bile chez le rat
Year: 1980
Type: article
Abstract: Effect of amount and mode of triglyceride administration on the absorption and the hydrolysis rates of rat native bile phosphatidylcholine.The paper reports how exogenous triglycerides, present in the intestinal lumen, modify the hydrolysis rates of bile phosphatidylcholine and the absorption of non-hydrolysed and hydrolysed bile lipids.The exogenous triglyceride was either given in a meal (experiment A) or injected into the intestinal lumen (experiment B).Experiment A : Group E l received a meal with 480 mg of olive oil added with a tracer dose o f tri (1-14 C) oleoyl glycerol.Group T, received a similar meal but without fat.Two hours later, the rats received in the duodenum 0.1 ml of bile (86.5 p. 100 of the radioactivity of the phosphatidylcholine labelled with (9-10 3 H 2 ) oleic acid) ; they were killed 90 min later.In the intestinal lumen, small amounts of exogenous and endogenous lipids (< 20 mg) were found ; they changed neither the bile lipid absorption (70-75 p. 100 of the radioactive dose disappeared from the lumen) nor the hydrolysis rate of bile phosphatidylcholine which remained the main radioactive lipid of the intestinal lumen and mucosa.Experiment B : The rats were fitted with a bile and a lymph fistula.Group E 2 received 6 injections in the duodenum at 1-hour intervals ; each injection (one per hour) contained 80 mg of trioleoyl glycerol and 0.5 ml of bile (93 p. 100 of the radioactivity of the phosphati-
DOI: 10.1051/rnd:19800721
Authors: Micheline BOQUILLON, Ph. BOUCROT, Monique CHABIN, Marguerite-Marie BOUTILLON, J. GRESTI
Language: French
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2012992045