Work

Update on the epidermal differentiation complex

Year: 2011

Type: review

Abstract: On human chromosome 1q21, a 2-Mb region called the epidermal differentiation complex comprises many genes encoding structural and regulatory proteins that are of crucial importance for keratinocyte differentiation and stratum corneum properties. Apart from those for involucrin and loricrin, most of the genes are organized in four families: the genes encoding EF-hand calcium-binding proteins of the S100A family, the genes encoding the small proline rich proteins (SPRRs) and the late cornified envelope (LCE) proteins, two families of cornified cell envelope components, and the genes encoding the S100-fused type proteins (SFTPs). This review focuses on the SPRRs, LCE proteins and SFTPs. It describes their structures, their specific functions and, when known, the mechanisms involved in the regulation of their expression. It also highlights their possible involvement in skin diseases.

Source: Frontiers in bioscience

DOI: 10.2741/4001

Author: Julie Henry

Institutions: Centre National de la Recherche Scientifique, Inserm

Language: English

Topic: Skin and Cellular Biology Research

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: Les Laboratories Pierre Fabre, Institut National de la Santé et de la Recherche Médicale, Centre National de la Recherche Scientifique, Société Française de Dermatologie et de Pathologie Sexuellement Transmissible