Application of Eutectic Solvent to Preparation of Ibuprofen Suspension by Emulsion Evaporation Method
Year: 2014
Type: article
Abstract: Menthol was used as sublimate eutectic compound to prepare the volatile eutectic solvent by mixing with camphor, borneol orN-Ethyl-5-methyl-2-(1-methylethyl) cyclohexanecarboxamide (WS-3). The system of menthol:camphor, menthol:borneol and menthol:WS-3 in various ratio (1:9 to 9:1) was characterized. The 5:5 menthol:camphor system showed the highest evaporation rate. Ibuprofen dissolved in eutectic solvent was used as internal phase of emulsion whereas tween80 was used as emulsifier. Eutectic solvent was evaporated to induce the transformation of emulsion droplet to small particle. Eutectic could be used as solvent for preparing small size suspension (14.81±0.44 µm) without organic solvent used.
Source: Advanced materials research
Institution: Silpakorn University
Language: English
Subfield: Physical and Theoretical Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: hybrid
OpenAlex ID: W2013291359