Work

Development of Potent Inhibitors of Pyocyanin Production inPseudomonas aeruginosa

Year: 2015

Type: article

Abstract: The development of new approaches for the treatment of antimicrobial-resistant infections is an urgent public health priority. The Pseudomonas aeruginosa pathogen, in particular, is a leading source of infection in hospital settings, with few available treatment options. In the context of an effort to develop antivirulence strategies to combat bacterial infection, we identified a series of highly effective small molecules that inhibit the production of pyocyanin, a redox-active virulence factor produced by P. aeruginosa. Interestingly, these new antagonists appear to suppress P. aeruginosa virulence factor production through a pathway that is independent of LasR and RhlR.

Source: Journal of Medicinal Chemistry

DOI: 10.1021/jm5015082

Authors: Laura C. Miller, Colleen T. O’Loughlin, Zinan Zhang, Albert Siryaporn, Justin E. Silpe, Bonnie L. Bassler, Martin F. Semmelhack

Institutions: Princeton University, Howard Hughes Medical Institute, University of California, San Francisco, National Institutes of Health

Language: English

Topic: Bacterial biofilms and quorum sensing

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Science Foundation, Howard Hughes Medical Institute, National Institutes of Health, National Institute of General Medical Sciences, National Institute of Allergy and Infectious Diseases, Air Force Office of Scientific Research

Awards: Predoctoral Training in Genetics and Molecular Biology, G3311016733, Negative regulation of virulence in Pseudomonas aeruginosa, Intra- and Inter Species Communication in Bacteria, Intercellular Signaling in Vibrio Harveyi

OpenAlex ID: W2013299789

FWCI: 2.307

Cites: 42

Cited by: 63

Related to: 10