This work has been retracted.
RETRACTED: Testis-specific protein on Y chromosome ( TSPY ) represses the activity of the androgen receptor in androgen-dependent testicular germ-cell tumors
Year: 2010
Type: article
Abstract: Testis-specific protein on Y chromosome (TSPY) is an ampliconic gene on the Y chromosome, and genetic interaction with gonadoblastoma has been clinically established. However, the function of the TSPY protein remains to be characterized in physiological and pathological settings. In the present study, we observed coexpression of TSPY and the androgen receptor (AR) in testicular germ-cell tumors (TGCTs) in patients as well as in model cell lines, but such coexpression was not seen in normal testis of humans or mice. TSPY was a repressor for androgen signaling because of its trapping of cytosolic AR even in the presence of androgen. Androgen treatment stimulated cell proliferation of a TGCT model cell line, and TSPY potently attenuated androgen-dependent cell growth. Together with the finding that TSPY expression is reduced in more malignant TGCTs in vivo, the present study suggests that TSPY serves as a repressor in androgen-induced tumor development in TGCTs and raises the possibility that TSPY could be used as a clinical marker to assess the malignancy of TGCTs.
Institutions: Institute for Quantitative Biosciences, The University of Tokyo, The University of Tokyo, Kyoto Prefectural University of Medicine, Japan Science and Technology Agency, Iwate Medical University, The University of Osaka, Research Center for Advanced Science and Technology, The University of Tokyo, Gunma University, Institute for Molecular and Cellular Regulation, Gunma University
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2013379183