Work

Diastereo- and Enantioselective Pd(II)-Catalyzed Additions of 2-Alkylazaarenes to N-Boc Imines and Nitroalkenes

Year: 2012

Type: article

Abstract: A chiral Pd(II)-bis(oxazoline) complex was found to be highly effective in promoting the first direct diastereo- and enantioselective addition of alkylazaarenes to N-Boc aldimines and nitroalkenes under mild conditions. Deprotection of Boc-protected products proceeded readily to provide amines in high yields.

Source: Journal of the American Chemical Society

DOI: 10.1021/ja3083494

Authors: Daniel Best, Szymon Kujawa, Hon Wai Lam

Institution: University of Edinburgh

Language: English

Topic: Asymmetric Synthesis and Catalysis

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funders: Engineering and Physical Sciences Research Council, FP7 Ideas: European Research Council

Awards: Increasing the Efficiency of Chemical Synthesis Using Asymmetric Transition Metal Catalysis, Enantioselective Transition Metal Catalysis for Efficient Chemical Synthesis