Work

PReS-FINAL-2181: Recombinant il-1ra restores the il-18-nk cell axis in steroid naive systemic juvenile idiopathic arthritis

Year: 2013

Type: article

Abstract: Systemic onset juvenile idiopathic arthritis (sJIA) is an acquired auto-inflammatory disease characterized by systemic inflammation and innate immune activation reflected in uncontrolled production of cytokines such as IL-1, IL-6 and IL-18. In sJIA, NK cell function is severely hampered despite high levels of IL-18. We recently found that defective phosphorylation of the IL-18 receptor beta is responsible for the deficient IL-18-NK cell axis in sJIA.

Source: Pediatric Rheumatology

DOI: 10.1186/1546-0096-11-s2-o16

Authors: W De Jager, SJ Vastert, G Mijnheer, BJ Prakken, NM Wulffraat

Institution: University Medical Center Utrecht

Language: English

Topic: Autoimmune and Inflammatory Disorders Research

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,090