Work

Preparation of Naphthoquinone Derivatives from Plumbagin and Their Ichthyotoxicity.

Year: 1997

Type: article

Abstract: Various naphthoquinone derivatives were prepared from a natural product, 5-hydroxy-2-methyl-1, 4-naphthoquinone (plumbagin); these were mostly substituted at C-3 through carbon-carbon bond formation mediated by a metal-based oxidant such as lead tetraacetate in the presence of various carboxylic acids. The halogenated compounds showed stronger ichthyotoxicity than plumbagin, but other derivatives were less active.

Source: Chemical and Pharmaceutical Bulletin

DOI: 10.1248/cpb.45.437

Authors: Kazuhito OGIHARA, Rieko YAMASHIRO, Matsutake HIGA, Seiichi YOGI

Institution: University of the Ryukyus

Language: English

Topic: Bioactive Compounds and Antitumor Agents

Subfield: Toxicology

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

Open Access status: bronze

OpenAlex ID: W2014590875

FWCI: 1.019

Cites: 2

Cited by: 15

Related to: 10